

  
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<meta charset="utf-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1">
<meta name="description" content="">
<meta name="author" content="">
<link rel="shortcut icon" href="http://spec-graphics.com/test/tox21/img/tox21.ico">
<link href='https://fonts.googleapis.com/css?family=EB+Garamond' rel='stylesheet' type='text/css'>


<link href="css/bootstrap.min.css" rel="stylesheet">

<link href="css/navigation.css" rel="stylesheet">
<link href="css/style.css" rel="stylesheet"> 


<style>
.blink_me {
    -webkit-animation-name: blinker;
    -webkit-animation-duration: 1s;
    -webkit-animation-timing-function: linear;
    -webkit-animation-iteration-count: infinite;
    
    -moz-animation-name: blinker;
    -moz-animation-duration: 1s;
    -moz-animation-timing-function: linear;
    -moz-animation-iteration-count: infinite;
    
    animation-name: blinker;
    animation-duration: 1s;
    animation-timing-function: linear;
    animation-iteration-count: infinite;
}

@-moz-keyframes blinker {  
    0% { opacity: 1.0; }
    50% { opacity: 0.0; }
    100% { opacity: 1.0; }
}

@-webkit-keyframes blinker {  
    0% { opacity: 1.0; }
    50% { opacity: 0.0; }
    100% { opacity: 1.0; }
}

@keyframes blinker {  
    0% { opacity: 1.0; }
    50% { opacity: 0.0; }
    100% { opacity: 1.0; }
}
</style>
<noscript>
<div style="color:#ffffff;background-color:#ff0000;height:40px;font-weight:bold;text-align:center;">
 <div ><span class="blink_me ">For full functionality of this site it is necessary to enable JavaScript.</span>
  <a href="http://www.enable-javascript.com/" target="_blank">Here </a><span class="blink_me ">are the
 instructions how to enable JavaScript in your web browser.</span></div>
 </div>
</noscript>
<html>
<body>
	<div class="ribbon"></div>
	<div class="container">
		<div class="ribbon-art">
	<a href="http://www.hhs.gov" target="new"><img src="img/hhs.png" alt="U.S. Department of Health &amp; Human Services" /></a> <a href="http://www.hhs.gov"
		title="U.S. Department of Health &amp; Human Services" target="new">U.S. Department of Health & Human Services </a> <img src="img/divider.png" alt="" /><a href="http://www.nih.gov" target="new"><img
		src="img/nih-ribbon.png" alt="National Institutess of Health" /></a> <a href="http://www.nih.gov" title="National Institutess of Health" target="new">National Institutes of Health</a><img
		src="img/divider.png" alt="" /> 
</div>


<div class="row banner">

	<div class="col-md-10 NCATS-logo">
		<table border="0">
			<tbody>
				<tr>
					<td><a href="http://www.ncats.nih.gov" target="new"><img src="img/NIH_NCATS_Master_Logo.png" alt="National Center for Advancing Translational Sciences" /></a></td>
					<td class="brand">Tox21 Data Challenge 2014</td>
					
				</tr>
			</tbody>
		</table>
	</div>
	<!--END col-md-10 NCATS-logo-->
	<div class="col-md-2 text-center">

		
			
			
				<button type="button" class="btn btn-block btn-default login btn-width100" data-toggle="modal" data-target="#loginModal">
					<img src="img/login.png" align="middle" alt="">Login
				</button>
			
		



		<div class="modal fade" id="loginModal" tabindex="-1" role="dialog" aria-labelledby="purchaseLabel" aria-hidden="true">
        	<div class="modal-dialog">
           	 <div class="modal-content">
                <div class="modal-header"><button type="button" class="close" data-dismiss="modal" aria-hidden="true">&times;</button>
                   <div class="panel panel-default">
  						<div class="panel-heading"><h3 class="panel-title"><strong>Login </strong></h3></div>
  							<div class="panel-body">
  							 
  							  <div>
										<a href="#" onclick="window.location.href='https://tripod.nih.gov/servlet/auth/persona.html?callback=https://tripod.nih.gov/tox21/challenge/signedin'">
										<!-- <a href="#" onclick="window.location.href='https://tripod.nih.gov/servlet/auth/persona.html?callback=http://balmer.ncats.nih.gov:8080/tmc/signedin'"> -->
										<img src="img/persona.jpeg" style="width: 160px;">
										<br/>
										 Login with Mozilla Persona
										 </a>
										 <div class="warn"></div>
									</div>
									<div id="persona_1">
										<img src="img/work.png" style="vertical-align:text-bottom"> How does Mozilla Persona work?
									</div>
  							</div><!--END panel-body-->
						</div><!--END panel-heading-->
               		 </div><!--END panel panel default-->
            	</div><!--END modal-header-->
       		 </div><!--END modal-content-->
    		</div><!--END modal-dialog-->
        

	<div class="modal fade" id="registerModal" tabindex="-1" role="dialog" aria-labelledby="purchaseLabel" aria-hidden="true">
		<div class="modal-dialog">
			<div class="modal-content">
				<div class="modal-header">
					<button type="button" class="close" data-dismiss="modal" aria-hidden="true" onclick="window.location.href='index.jsp'">&times;</button>
					<div class="panel panel-default">
						<div class="panel-heading">
							<h3 class="panel-title">
								<strong>Register with Mozilla Persona </strong>
							</h3>
						</div>
						<div class="panel-body">
							 
								<div class="with-border">
									<div>
										<a href="#" onclick="window.location.href='https://tripod.nih.gov/servlet/auth/persona.html?callback=https://tripod.nih.gov/tox21/challenge/registration'">
										<img src="img/persona.jpeg" style="width: 160px;"> 
									 	<br/>
										 Sign Up with Mozilla Persona</a>
										 <div class="warn"></div>
									</div>
									<div id="persona_2">
										<img src="img/work.png" style="vertical-align:text-bottom"> How does Mozilla Persona work?
									</div>
								</div>
								<!--END panel-body-->
							 
							<!--END panel-heading-->
						</div>
						<!--END panel panel default-->
					</div>
					<!--END modal-header-->
				</div>
				<!--END modal-content-->
			</div>
			<!--END modal-dialog-->

		</div>
		<!--END col-md-2 text-center-->
		</div>
		</div>
		</div>
		
		
		<div style="display: none" id="whatispersona">
		<p>
			<a href="https://support.mozilla.org/en-US/kb/what-is-persona-and-how-does-it-work"><img src="img/persona.jpeg" style="float:left;padding:10px; width:100px;height:80px"></a>
		</p>
		<p class="card"> 
			<p>Persona lets you log in to websites using only your email address! Persona lets you prove your identity to websites through your email address without giving them any passwords. 
			This works similarly to how you prove your identity when you show someone your ID: websites can easily verify that your ID is authentic and that you really are the person it was issued to. 
		</p>
		<h4>What are the benefits of Mozilla Persona?</h4>
		<ul><li>You can use one easy-to-remember log in for all sites that support Persona.
		</li><li>You never have to trust a website with your password because they never know it. Also, your password can't be stolen if one of those websites gets hacked.
		</li><li>You can use Persona with as many email addresses as you want. This lets you keep your various online personalities (school, work, home, etc.) separate.
		</li><li>Persona doesn't let your email provider track what websites you visit.
		</li></ul>
		<a href="https://support.mozilla.org/en-US/kb/what-is-persona-and-how-does-it-work">More information about Mozilla Persona. </a>
		</p>
	</div>
		

		<div class="masthead">
			 
<div ID="skipthis"><a href="#skipnav">Skip repetitive links</a></div>
<ul class="nav nav-justified">
<li><a href="index.jsp" id="index">Home</a></li>
<li><a href="about.jsp" id="about">About</a></li> 

 
<li><a href="registration.jsp" id="registration">Registration</a></li>


<!-- <li><a href="#"  id="registration" data-toggle="modal" data-target="#registerModal">Registration</a></li> -->
<li><a href="data.jsp" id="data">Data/Resources</a></li>
<li><a href="submissions.jsp" id="submissions">Submissions</a></li>
<li><a href="discussion.jsp" id="discussion">Discussion</a></li>
<li><a href="leaderboard.jsp" id="leaderboard">Leaderboard</a></li>
<li><a href="contact.jsp" id="contact">Contact Us</a></li>
<!-- <li><a href="#" onclick="showSurvey()">Survey <img src="img/new.gif"></a></li>-->
<!-- <li class="dropdown"> <a href="#" class="dropdown-toggle" data-toggle="dropdown">Other<span class="caret"></span></a>
            <ul class="dropdown-menu" role="menu">
                <li><a href="other1.jsp" data-toggle="tab">other 1</a>
                </li>
                <li><a href="other2.jsp" data-toggle="tab">other 2</a>
                </li>
            </ul>
</li> -->
</ul>
<div class="jumbotron"  style="margin:10px">
<img src="img/tox-logo.png" class="img-responsive" alt="Tox21">    
</div>

<script type="text/javascript">

function showSurvey(){
	window.open('survey.html','','width=780, height=1000, scrollbars=yes, resizable=yes');
}
</script>
		</div>
		<!--END masthead-->


		<div id="h1-heading">
			<h1 ID="skipnav">About the Challenge</h1>
		</div>

		<div class="row">
			<div class="col-md-4">
				<div class="panel panel-primary">
					<div class="panel-heading">
						<h3 class="panel-title">What is Tox 21? <span class="glyphicon glyphicon-info-sign bs-icon"> </span></h3>
					</div>
					<div class="panel-body">
						<p>
							<img src="img/5964662787.jpg" class="thumbnail img-responsive" alt="" />
						</p>
						<p>Most people are exposed to many different chemicals during the course of their lifetimes through sources including food, household cleaning products and medicines. In some cases, these
							chemicals can be toxic.</p>
						<p>
							In fact, more than 30 percent of promising pharmaceuticals have failed in human clinical trials because they are determined to be toxic despite promising pre-clinical studies in animal models (<em>Nat
								Rev Drug Discov.</em> 2004;3(8):711&#8211;715). Creating new methods for assessing chemical toxicity has the potential to improve how scientists evaluate environmental chemicals and develop new
							medicines.
						</p>
						<p>
							<a href="http://www.ncats.nih.gov/research/reengineering/tox21/tox21.html">The Toxicology in the 21st Century (Tox21) program</a>, a federal collaboration involving NIH, the Environmental
							Protection Agency, and the Food and Drug Administration, is aimed at developing better toxicity assessment methods. The goal is to quickly and efficiently test whether certain chemical
							compounds have the potential to disrupt processes in the human body that may lead to adverse health effects.
						</p>
						<p>The Tox21 consortium leverages its partners&#39; resources and expertise to predict more effectively how a collection of 10,000 compounds composed of environmental chemicals and approved
							drugs will affect human health and the environment.</p>
						<p>
							<a class="btn btn-default" href="http://www.ncats.nih.gov/research/reengineering/tox21/tox21.html" role="button" Target="_blank">Learn More &raquo;</a>
						</p>
					</div>
				</div>
			</div>


			<div class="col-md-8">
				<div class="panel panel-default">
					<div class="panel-body">
						<h3>Challenge Overview</h3>
						<p>The goal of the challenge is to &quot;crowdsource&quot; data analysis by independent researchers to reveal how well they can predict compounds&#39; interference in biochemical pathways using only
							chemical structure data.  The computational models produced from the Challenge could become decision-making tools for government agencies 
							in determining which environmental chemicals and drugs are of the greatest potential concern to human health.</p>

						<h4>The Challenge</h4>
						<p>Use data generated from nuclear receptor signaling and stress pathway assays run against Tox21&#39;s 10,000-compound library (Tox21 10K) to build models and look for structure-activity relationships.</p>
						<p>Participants have the opportunity to join 15 distinct subchallenges:</p>
						<ul>
							<li>Subchallenges 1&#8211;12 use data from a single assay.</li>
							<li>Subchallenges 13 and 14 capture all assays of a specific type (nuclear receptor signaling (NR) or stress response (SR)).</li>
							<li>Subchallenge 15 captures all assays of both types.</li>
						</ul>
						<p>Participants can choose to join one or all of the subchallenges. There will be one winner for each subchallenge.</p>
					</div>
				</div>

			</div>

			<div class="col-md-8">
				<div class="panel panel-default">
					<div class="panel-body">
						<h3>Subchallenge Overview</h3>
						<h4>Subchallenges 1&#8211;12</h4>
						<p>Predict the compound activity outcome (active or inactive) in one or more of the 12 pathway assays based on the chemical structure information for the following assays:<br/>
						 <ul>
						 <li>estrogen receptor alpha, LBD (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743077" target="_blank">ER, LBD</a>)</li> 
						 <li>estrogen receptor alpha, full (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743079" target="_blank">ER, full</a>) </li> 
						 <li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743139" target="_blank">aromatase</a> </li> 
						 <li>aryl hydrocarbon receptor (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743122" target="_blank">AhR</a>) </li> 
						 <li>androgen receptor, full (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743040" target="_blank">AR, full</a>) </li> 
						 <li>androgen receptor, LBD (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743053" target="_blank">AR, LBD</a>) </li> 
						 <li>peroxisome proliferator-activated receptor gamma (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743140" target="_blank">PPAR-gamma</a>) </li> 
					 
						 <li>nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743219" target="_blank">Nrf2/ARE</a>) </li> 
						 <li>heat shock factor response element (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743228" target="_blank">HSE</a>) </li> 
						 <li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720516" target="_blank">ATAD5</a> </li> 
						 <li>mitochondrial membrane potential (<a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720637" target="_blank">MMP</a>) </li>
						 <li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720552" target="_blank">p53</a></li> 
						 </ul>
						 </p>
						<p>
							<b>NOTE:</b> Participants can do 1 <a href="data.jsp">data set</a> or multiple <a href="data.jsp">data sets</a>. There is no limit here. However, if participants choose to do all 12, then
							that&#39;s considered the Grand Challenge.
						</p>

						<h4>Subchallenge 13 (Panel)</h4>
						<p>Predict compound activity in all nuclear receptor signaling pathways.</p>
						<p>
						
						<ul>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743040" target="_blank">AR</a></li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743122" target="_blank">AhR</a></li> 
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743053" target="_blank">AR-LBD</a></li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743079" target="_blank">ER</a></li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743077" target="_blank">ER-LBD</a></li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743139" target="_blank">aromatase</a></li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743140" target="_blank">PPAR-gamma</a></li>
						</ul>
						</p>


						<h4>Subchallenge 14 (Panel)</h4>
						<p>Predict compound activity in all stress response pathways.</p>
						<p>
						
						<ul>  
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743219" target="_blank">ARE</a>
							</li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720516" target="_blank">ATAD5</a>
							</li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=743228" target="_blank">HSE</a>
							</li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720637" target="_blank">MMP</a>
							</li>
							<li><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=720552" target="_blank">p53</a>
							</li>
						</ul>
						</p>

						<h4>Subchallenge 15 (Grand Challenge)</h4>
						<p>Predict compound activity in all of the above-mentioned assays, collectively.</p>
					</div>
				</div>
			</div>

			<!-- <div class="col-md-8">
				<div class="panel panel-default">
					<div class="panel-body">
						<h3>Background Resources for Teams</h3>
						<ul>
							<li><a href="http://www.ncats.nih.gov/research/reengineering/tox21/tox21.html">Tox21 at NCATS</a></li>
							<li><a href="http://epa.gov/ncct/Tox21/" TARGET="_blank">Tox21 at the Environmental Protection Agency</a></li>
							<li><a href="http://ntp.niehs.nih.gov/?objectid=05F80E15-F1F6-975E-77DDEDBDF3B941CD" TARGET="_blank">Tox21 at the National Toxicology Program/National Institute of Environmental Health
									Sciences</a></li>
							<li><a href="http://www.ncats.nih.gov/research/reengineering/tox21/projects/compound-toxicity.html">Tox21 Robot at NCATS</a></li>
						</ul>

						<hr>
						<h4>Key Dates<img src="img/signal.gif" style="vertical-align:text-bottom;"></h4>
						<p>
							<strong>August 2014</strong><br>NCATS begins accepting submissions
						</p>
						<p>
							<strong>November 14, 2014 (11:59 p.m. PT)</strong><br>Registration and submission deadline
						</p>
						<p>
							<strong>January 12, 2015</strong><br>Winners announced
						</p>
						<p>
							<a class="btn btn-default" href="registration.jsp" role="button">Register Now &raquo;</a>
						</p>

					</div>
				</div>
			</div> -->
		</div>

		<div id="bottom-border"></div>
	</div>
	 

<div id="footer">
<div class="row">
   			<div class="col-md-12">
   				<p><a href="https://www.nih.gov/" target="_blank" rel="noopener noreferrer" class="external-link">NIH</a> <span class="v-bar">|</span>
   				<a href="https://ncats.nih.gov/" target="_blank" rel="noopener noreferrer" class="external-link">NCATS</a> <span class="v-bar">|</span>
   				<a href="https://ncats.nih.gov/privacy" target="_blank" rel="noopener noreferrer" class="external-link">PRIVACY ACT</a> <span class="v-bar">|</span>
   				<a href="https://ncats.nih.gov/accessibility" target="_blank" rel="noopener noreferrer" class="external-link">ACCESSIBILITY</a> <span class="v-bar">|</span>
   				<a href="https://ncats.nih.gov/disclaimer" target="_blank" rel="noopener noreferrer" class="external-link">DISCLAIMER</a></p>
   			</div>
   		</div>
   		<div class="row">
   			<div  class="col-md-12">
   				<a title="HHS Vulnerability Disclosure" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="external-link" target="_blank">HHS Vulnerability Disclosure</a>
   			</div>
   		</div>
   		<div class="row">
   			<div class="col-md-12"> 
   				<p>If you have problems viewing PDF files, download the latest version of <a target="_blank" href="https://get.adobe.com/reader/" class="external-link">Adobe Reader</a></p>
   			</div>
   		</div>
   
    	<div class="row">
   			<div class="col-md-12"> 
   				<p>For <a href="http://edi.nih.gov/consulting/language-access-program/about" target="_blank" title="Read the plan" class="external-link">language access</a> assistance, 
   				contact the <a href="mailto: info@ncats.nih.gov" title="E - mail Public Information Officer" class="external-link">NCATS Public Information Officer</a></p>
   			</div>
   		</div>
   
    	<div class="row">
    		<div class="col-md-12"> 
   				<p>National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 &#9742; 301-594-8966</p>
   			</div>
   		</div> 
</div>	

 <!-- Bootstrap core JavaScript -->

<script src="js/jquery.min.js"></script>
<!-- <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.0/jquery.min.js"></script> -->
<script src="js/bootstrap.min.js"></script>
<script src="js/util.js"></script>

<!-- hover card -->
<script src="js/jquery.hovercard.min.js"></script>
<script>
 
(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function()
{
  (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new
Date();a=s.createElement(o),
 
m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(
a,m)
 
})(window,document,'script','//www.google-analytics.com/analytics.js','ga')
;

  ga('create', 'UA-18970667-1', 'auto');
  ga('send', 'pageview');

</script>




</body>
</html>